Zero Leader is based on the Corsair Leader game, with some significant changes. The game focuses on commanding and managing a Japanese aerial squadron in the Pacific in World War Two, with aircraft including the A6M2 Zero, KI-84 Frank, KI-43 Oscar, G4M Betty, and G3M Nell, covering the major campaigns throughout the war from 1941 to 1945.

You will need to select the right mix of aircraft under your command in order to successfully carry out the different types of missions. Each aircraft has its advantages and disadvantages. For example, a fighter like the Zero is very maneuverable and deadly to enemy Bandits, but it has limited ability to attack naval and ground targets, whereas a bomber like the Betty can carry a lot of munitions, but are susceptible to enemy bandit and anti-aircraft attacks.

This game also includes additional aspects of Japanese operations such as mechanical and maintenance challenges, invoking samurai spirit, as well as the ability to deploy the deadly Ohka kamikaze aircraft-bombs. There is also an air combat system which gives you more tactical options when dog-fighting with enemy aircraft, including maneuvering for position, increasing pilot aggression and being affected by the robustness of the aircraft.

Like the other games in the "Leader" series, Zero Leader is a solitaire game.